our online journals are moving. The new (and old) issues of all journals can be found at
In most cases you can log in there directly with your e-mail address and your current password. Otherwise we ask you to register again. Thank you very much.
Your Quintessence Publishing House
Oral Health Prev Dent 18 (2020), Open Access 12. Feb. 2020
Oral Health Prev Dent 18 (2020), Open Access (12.02.2020)
Open Access PERIODONTOLOGY, Online Article, Page 815-822, doi:10.3290/j.ohpd.a45086, PubMed:32895666
Online Article: Nonsurgical Periodontal Therapy Reduces Salivary and Gingival Crevicular Fluid YKL-40 and IL-6 Levels in Chronic Periodontitis
Keles Yucel, Zeynep Pinar / Keles, Gonca Cayir / Avci, Bahattin / Cetinkaya, Burcu Ozkan
Purpose: A novel acute-phase protein, YKL-40, is known as an inflammation-associated glycoprotein. YKL-40 is shown to be linked to inflammation, endothelial dysfunction and tissue remodeling secreted by various cells and is also considered to be stimulated by cytokines such as interleukin-6 (IL-6). The present study aimed to investigate YKL-40 and IL-6 levels in saliva and gingival crevicular fluid (GCF) of patients with chronic periodontitis (CP) after non-surgical periodontal therapy for the first time.
Materials and Methods: Twenty-six CP patients and 26 periodontally healthy individuals were enrolled. Clinical measurements were recorded; saliva and GCF samples were obtained at baseline and 1 and 3 months after non-surgical periodontal therapy. Levels of YKL-40 and IL-6 in saliva and GCF were analysed by ELISA.
Results: Salivary and GCF YKL-40 and IL-6 levels were found to be statistically significantly higher in CP patients compared to healthy controls at baseline (p < 0.001). At 1 and 3 months after the completion of treatment, both YKL-40 and IL-6 levels in saliva and GCF had statistically significantly decreased compared with baseline values in CP patients (p < 0.001). On the other hand, no statistically significant difference was observed between 1 and 3 months in terms of salivary and GCF YKL-40 and IL-6 levels or any of the clinical findings (p > 0.016).
Conclusion: Salivary and GCF YKL-40 levels may be useful to evaluate resolution of periodontal inflammation. Within the limits of this study, YKL-40 acute-phase protein might be a potential biomarker for detection of periodontitis and monitoring the response to periodontal therapy.
Keywords: after-treatment, gingival crevicular fluid, human, interleukin-6, saliva, YKL-40 protein