We are using cookies to implement functions like login, shopping cart or language selection for this website. Furthermore we use Google Analytics to create anonymized statistical reports of the usage which creates Cookies too. You will find more information in our privacy policy.
OK, I agree I do not want Google Analytics-Cookies
Oral Health and Preventive Dentistry



Forgotten password?


Dear readers,

our online journals are moving. The new (and old) issues of all journals can be found at
In most cases you can log in there directly with your e-mail address and your current password. Otherwise we ask you to register again. Thank you very much.

Your Quintessence Publishing House
Oral Health Prev Dent 18 (2020), Open Access     12. Feb. 2020
Oral Health Prev Dent 18 (2020), Open Access  (12.02.2020)

Open Access ORAL MEDICINE, Online Article, Page 799-806, doi:10.3290/j.ohpd.a45084, PubMed:32895664

Online Article: The Effects of Gardenia Jasminoides on Periodontitis in Ligature-Induced Rat Model
Lee, Dae Hoon / Lee, Haesu / Kim, Mi Hye / Yang, Woong Mo
Purpose: Periodontitis is characterised by inflammation of periodontium and alveolar bone loss. Gardenia jasminoides is reported to have anti-inflammatory effects. In this study, we investigated the effects of aqueous extract of G. jasminoides (GJ) on periodontitis.
Materials and Methods: Male Sprague-Dawley rats aged 7 weeks were randomly placed in three groups (n = 7); non-ligatured and non-treated (NL group), ligatured and distilled water-treated (L group) and ligatured and 100 mg/kg GJ-treated (GJ group). After oral administration of GJ for 14 days, the mandibles were removed for histology. In addition, RAW 264.7 cells were treated with 100 ng/ml receptor activator of nuclear factor-κΒ ligand (RANKL) and 1, 10 and 100 μg/ml GJ for 7 days to analyse the expression of periodontitis-related factors.
Results: In GJ-treated mice, the score of alveolar bone loss was statistically significantly attenuated compared with the L group. GJ treatment showed inhibition effect in the progress of cementum demineralisation. The expressions of proinflammatory cytokines in gingival tissue were statistically significantly regulated by GJ treatment. Additionally, GJ treatment showed the dose-dependent inhibition of RANKL-induced osteoclast formation. Furthermore, GJ treatment downregulated the RANKL-induced cytokine production in RAW 264.7 cells.
Conclusion: In summary, GJ ameliorated periodontitis-induced alveolar bone loss via inhibiting transcription factors including nuclear factor-κB, c-fos and extracellular signal-regulated kinase signalling. Therefore, GJ might be a therapeutic option for treating periodontitis.

Keywords: periodontitis, Gardenia jasminoides, alveolar bone loss, osteoclasts