We are using cookies to implement functions like login, shopping cart or language selection for this website. Furthermore we use Google Analytics to create anonymized statistical reports of the usage which creates Cookies too. You will find more information in our privacy policy.
OK, I agree I do not want Google Analytics-Cookies
Oral Health and Preventive Dentistry
Login:
username:

password:

Plattform:

Forgotten password?

Registration

Oral Health Prev Dent 18 (2020), No. 2     1. Apr. 2020
Oral Health Prev Dent 18 (2020), No. 2  (01.04.2020)

Open Access PERIODONTOLOGY, Online Article, Page 171-175, doi:10.3290/j.ohpd.a43493, PubMed:32238989


Online Article: Lack of Association Between the VEGFA Gene Rs699947 Polymorphism and Periodontal Disease
Mazurek-Mochol, Małgorzata / Łagocka, Ryta / Dembowska, Elżbieta / Kozak, Małgorzata / Sawczuk, Marek / Maciejewska, Agnieszka / Malinowski, Damian / Safranow, Krzysztof / Pawlik, Andrzej
Purpose: Periodontal disease is a chronic inflammatory disease characterised by the infiltration of inflammatory cells as well as activation of pathological angiogenesis in gingival tissues. Vascular endothelial growth factor (VEGF) plays a statistically significant role in the regulation of angiogenesis and induction of an inflammatory response in periodontal tissues.
Materials and Methods: We examined the association between the VEGFA gene rs699947 polymorphism and periodontal disease. This study enrolled 200 patients with periodontal disease (130 non-smokers and 70 smokers) and 160 control subjects (126 non-smokers and 34 smokers).
Results: There were no statistically significant differences in the distribution of VEGFA rs699947 genotypes and alleles between patients with periodontal disease and control subjects, also in the case when the analysis was performed in subgroups stratified according to smoking status.
Conclusion: The results of this study suggest there is no association between the VEGFA gene rs699947 polymorphism and periodontal disease.

Keywords: gene, polymorphism, periodontal disease, VEGFA