We are using cookies to implement functions like login, shopping cart or language selection for this website. Furthermore we use Google Analytics to create anonymized statistical reports of the usage which creates Cookies too. You will find more information in our privacy policy.
OK, I agree I do not want Google Analytics-Cookies
Oral Health & Preventive Dentistry



Forgotten password?


Oral Health Prev Dent 11 (2013), No. 1     14. Mar. 2013
Oral Health Prev Dent 11 (2013), No. 1  (14.03.2013)

Page 61-69, doi:10.3290/j.ohpd.a29377, PubMed:23507683

Anti-inflammatory Effect of Vitamin D on Gingivitis: A Dose-Response Randomised Control Trial
Hiremath, Vishwanath P. / Rao, C. Bhasker / Naik, Vijaya / Prasad, Kakrala Veera Venkatesha
Purpose: To assess the anti-inflammatory effect of vitamin D on gingivitis at various doses.
Materials and Methods: In this randomized controlled trial, daily oral vitamin D supplementation was given in doses of 2000 IU for group A, 1000 IU for group B, 500 IU for group C and a placebo for group D over a 3-month period. The changes in gingival scores were measured after the 1st, 2nd and 3rd months.
Results: The gingivitis score changed in direct proportion to the dose of vitamin D supplementation. In group A, the mean gingival scores were 2.4 (baseline), 1.7 after the first month, 0.8 after the second month and 0.3 after the third month. The group B mean baseline gingival score of 2.3 decreased to 2.0 in the first month, 1.1 after the second month and 0.5 after the third month. In group C, the baseline gingival scores were 2.2 and 1.9 after one month, 1.4 after two months and 0.8 by the last visit. Comparing baseline gingivitis scores with the later-visit score using the Wilcoxon paired test, the significant anti-inflammatory effect was seen in group A after one month, in group B at two months and in group C at three months after oral vitamin D supplementation (P < 0.0001). However, group D did not show a significant antiinflammatory effect.
Conclusion: There is a dose-dependent anti-inflammatory effect of vitamin D on gingivitis. Vitamin D is a safe and effective anti-inflammatory agent in doses ranging from 500 IU to 2000 IU. Results are apparent earlier with the higher dose of 2000 IU.
***This article is not available online.***

Keywords: anti-inflammatory effect, gingivitis, 25 hydroxyvitamin D
no fulltext available Endnote-Export